Much of the spam I receive is in Russian. As a side note, Russian characters have multiple encodings - WIN1251, KOI8-R, CP866, ISO-8859-5 and the universal UTF-8 come to mind. This means that the mail client has to properly understand the encoding and decode the message so that it can be displayed correctly.
I use Thunderbird, and it is just awful in decoding Russian messages. I don't have any idea why is that, but I have to manually specify encoding for every last message, because they always appear garbled.

But then, the bug becomes an unexpected feature - the spam messages look undecipherable just like legitimate ones, and even though I look at it, nothing is imprinted in my mind, and I just hit "Delete".